EdenteV2, France, Analysis, bibRecord, 000039

A pre-clinical murine model of oral implant osseointegration

Identifieur interne : 000039 ( France/Analysis ); précédent : 000038; suivant : 000040

A pre-clinical murine model of oral implant osseointegration

Auteurs : S. Mouraret [États-Unis, France] ; D. J. Hunter [États-Unis] ; C. Bardet [États-Unis, France] ; J. B. Brunski [États-Unis] ; P. Bouchard [France] ; J. A. Helms [États-Unis]

Source :

Bone : (New York, NY) [ 8756-3282 ] ; 2014.

RBID : Pascal:14-0062686

Descripteurs français

Pascal (Inist)
- Animal, Souris, Modèle, Dent, Histologie, Maxillaire, Cavité buccale, Morphologie, Dentisterie, Traitement, Implant dentaire.
Wicri :
- topic : Histologie.

English descriptors

KwdEn :
- Animal, Dental implant, Dentistry, Histology, Maxillary, Models, Morphology, Mouse, Oral cavity, Tooth, Treatment.

Abstract

Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones. This disconnect between clinical practice and experimental research hampers our understanding of bone formation around oral implants and how this process can be improved. We postulated that oral implant osseointegration would be fundamentally equivalent to implant osseointegration elsewhere in the body. Mice underwent implant placement in the edentulous ridge anterior to the first molar and peri-implant tissues were evaluated at various timepoints after surgery. Our hypothesis was disproven; oral implant osseointegration is substantially different from osseointegration in long bones. For example, in the maxilla peri-implant pre-osteoblasts are derived from cranial neural crest whereas in the tibia peri-implant osteoblasts are derived from mesoderm. In the maxilla, new osteoid arises from periostea of the maxillary bone but in the tibia the new osteoid arises from the marrow space. Cellular and molecular analyses indicate that osteoblast activity and mineralization proceeds from the surfaces of the native bone and osteoclastic activity is responsible for extensive remodeling of the new peri-implant bone. In addition to histologic features of implant osseointegration, molecular and cellular assays conducted in a murine model provide new insights into the sequelae of implant placement and the process by which bone is generated around implants.

Affiliations:

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to stream Main, to step Exploration: 002072
to stream France, to step Extraction: 000039

Links to Exploration step

Pascal:14-0062686

Le document en format XML

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<front><div type="abstract" xml:lang="en">Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones. This disconnect between clinical practice and experimental research hampers our understanding of bone formation around oral implants and how this process can be improved. We postulated that oral implant osseointegration would be fundamentally equivalent to implant osseointegration elsewhere in the body. Mice underwent implant placement in the edentulous ridge anterior to the first molar and peri-implant tissues were evaluated at various timepoints after surgery. Our hypothesis was disproven; oral implant osseointegration is substantially different from osseointegration in long bones. For example, in the maxilla peri-implant pre-osteoblasts are derived from cranial neural crest whereas in the tibia peri-implant osteoblasts are derived from mesoderm. In the maxilla, new osteoid arises from periostea of the maxillary bone but in the tibia the new osteoid arises from the marrow space. Cellular and molecular analyses indicate that osteoblast activity and mineralization proceeds from the surfaces of the native bone and osteoclastic activity is responsible for extensive remodeling of the new peri-implant bone. In addition to histologic features of implant osseointegration, molecular and cellular assays conducted in a murine model provide new insights into the sequelae of implant placement and the process by which bone is generated around implants.</div>
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A pre-clinical murine model of oral implant osseointegration

A pre-clinical murine model of oral implant osseointegration

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri